Effect of FC43se on endotoxin-induced disseminated intravascular coagulation in rats.

Effect of a Antagonist Septicemia Platelet Activating Factor and Antithrombin III on and Endotoxemia in Rats

INOUE, Y., KOHNO, S., MIYAZAKI, T. and YAMAGUCHI, K. Effect of a Platelet Activating Factor Antagonist and Antithrombin III on Septicemia and Endotoxemia in Rats. Tohoku J. Exp. Med., 1991, 163 (3), 175-185 Disseminated intravascular coagulation (DIC) or renal damage associated with septicemia was induced in rats by ligating the cecum or by injecting endotoxin. In the septicemia model, the numb...

The Role of Endotoxaemia in the development of Renal Disorders Experimental Obstructive Jaundice in Rats

In rats with 2-week obstructive jaundice the sensitivity to endotoxin was studied and the effect of a single dose of endotoxin on histological development in the kidney, liver and spleen was also investigated. We were tested the effect on accumulation and distribution within organs, of fibrinogen labelled with radioactive iodine I 125. We showed an increased sensitivity to endotoxin in obstruct...

Level and Effect of Adrenomedullin on Endotoxin Induced Disseminated Intravascular Coagulation Model in Rabbits

Adrenomedullin (ADM) is a regulatory peptide having a variety of pharmacological properties secreted from vascular endothelial cells and adrenal medulla. There are only a few studies about the effects of ADM on coagulation and platelets which is secreted from endothelial cells. The aim of this study is to assay ADM levels in rabbits with endotoxin induced disseminated intravascular coagulation ...

Disseminated Intravascular Coagulation in a Case of Brucellosis Misdiagnosed as Thrombotic Thrombocytopenia Purpura

Immunodepletion of extrinsic pathway inhibitor sensitizes rabbits to endotoxin-induced intravascular coagulation and the generalized Shwartzman reaction.

We have reported earlier that immunodepletion of extrinsic pathway inhibitor (EPI) sensitizes rabbits to disseminated intravascular coagulation (DIC) induced by infusing a low concentration of tissue factor (TF). We now describe the effect of immunodepletion of EPI in rabbits administered endotoxin. Cortisone-treated rabbits were administered anti-rabbit EPI immunoglobulin (IgG) or Fab fragment...